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Sinemet CR Oral

Generic Name: CARBIDOPA/LEVODOPA SUSTAINED-RELEASE - ORAL
Pronounced: (lee-voh-DOE-puh/car-beh-DOE-puh)

Sinemet CR Oral Side Effects

Dizziness, nausea, vomiting, trouble sleeping, and headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may cause your urine, sweat or saliva to turn red, brown, or black. This is harmless, but your clothes may become discolored.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • greatly increased eye blinking/twitching
  • irregular heartbeat
  • fainting
  • mental/mood changes (e.g., confusion, depression, hallucinations, thoughts of suicide)
  • worsening of involuntary movements/spasms


Tell your doctor immediately if any of these rare but very serious side effects occur:

  • easy bleeding/bruising
  • signs of infection (e.g., fever, persistent sore throat)
  • change in the appearance/size of moles or other unusual skin changes
  • tingling of the hands/feet
  • vision changes (e.g., blurred/double vision)


Seek immediate medical attention if any of these rare but very serious side effects occur:

  • chest pain
  • seizures
  • vomit that looks like coffee grounds
  • black/tarry stools


Abruptly stopping or reducing the dose of this medication may rarely cause a serious (sometimes fatal) condition (neuroleptic malignant syndrome). Seek immediate medical attention if any of these rare but very serious side effects occur:

  • fast/shallow breathing
  • confusion
  • severe dizziness/fainting
  • high fever
  • unusual muscle stiffness
  • unusual sweating


For males, in the very unlikely event you have a painful or prolonged erection (lasting more than 4 hours), stop using this drug and seek immediate medical attention or permanent problems could occur.

A very serious allergic reaction is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include:

  • rash
  • itching
  • swelling
  • severe dizziness
  • trouble breathing


This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

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