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Sinemet CR Oral

  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing


This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Sinemet CR Oral Precautions

Before taking this medication, tell your doctor or pharmacist if you are allergic to carbidopa or levodopa; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • certain eye problem (narrow-angle glaucoma)


Before using this medication, tell your doctor or pharmacist your medical history, especially of:

  • bleeding disorders
  • breathing problems (e.g., asthma, emphysema)
  • certain eye problem (wide-angle glaucoma)
  • heart or blood vessel problems (e.g., arrhythmias, heart attack, angina)
  • kidney disease
  • liver disease
  • mental/mood disorders (e.g., depression, schizophrenia)
  • peptic ulcer
  • seizure


This drug may make you dizzy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Avoid alcoholic beverages.

To minimize lightheadedness, get up slowly when rising from a sitting or lying position.

Before having surgery, tell your doctor or dentist that you are taking this medication.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

Levodopa may pass into breast milk and affect milk production. Consult your doctor before breast-feeding.

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