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Efudex Top

Generic Name: FLUOROURACIL - TOPICAL
Pronounced: (flewr-oh-YOUR-uh-sill)

Efudex Top Side Effects

Skin irritation, burning, redness, dryness, pain, swelling, tenderness, or changes in skin color may occur at the site of application. Eye irritation (e.g., stinging, watering), trouble sleeping, irritability, temporary hair loss, or abnormal taste in the mouth may also occur.

If any of these effects persist or worsen, contact your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these rare but very serious side effects occur:

  • stomach/abdominal pain
  • bloody diarrhea
  • vomiting
  • signs of infection (e.g., fever, chills, persistent sore throat)
  • easy bruising/bleeding
  • mouth sores


A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms:

  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing


This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. In the US, you may report side effects to the Food and Drug Administration (FDA) at 1-800-FDA-1088.

In Canada, you may report side effects to Health Canada at 1-866-234-2345.

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