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Hycamtin IV

Generic Name: TOPOTECAN - INJECTION
Pronounced: (toe-poh-TEE-kan)

Hycamtin IV Warning

Topotecan may cause very serious (possibly fatal) blood disorders (decreased bone marrow function leading to low number of blood cells such as white cells, red cells, and platelets). This effect can decrease your body's ability to fight an infection, cause your body to bruise or bleed easier, or cause anemia. Tell your doctor if you develop any of the following conditions: signs of an infection (such as fever, persistent sore throat), easy bruising/bleeding, unusual tiredness, fast/pounding heartbeat.

You will be closely monitored (e.g., with frequent blood tests) by your doctor while using this medication. Keep all medical and laboratory appointments.

Hycamtin IV Side Effects

See also Warning section.

Weakness, tiredness, headache, cough, nausea, vomiting, diarrhea, constipation, abdominal pain, loss of appetite, and mouth sores may occur. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating several small meals, not eating before treatment, or limiting activity may help lessen some of these effects. If these effects persist or worsen, tell your doctor or pharmacist promptly.

Temporary hair loss may occur. Normal hair growth should return after treatment has ended.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • pain/redness/bruising at injection site
  • numbness/tingling of the arms/legs
  • shortness of breath


Tell your doctor immediately if any of these rare but very serious side effects occur:

  • yellowing eyes/skin
  • dark urine


A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including:

  • rash
  • itching
  • swelling
  • severe dizziness
  • trouble breathing


This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Hycamtin IV Medical Alert

Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-800-854-1166 (USA) or 1-800-668-1507 (Canada).

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