Rapamune Oral

In Depth

Generic Name: SIROLIMUS - ORAL
Pronounced: (sir-oh-LEE-muss)

Rapamune Oral Warning

Sirolimus lowers the body's ability to fight an infection/disease (immunosuppression). This may increase your risk of developing an infection or certain types of cancer (e.g., skin cancer, lymphoma). To reduce the risk of these serious side effects, take this medication at the lowest effective dose as directed by your doctor. Keep all medical and laboratory appointments.

Tell your doctor immediately if you develop any of the following: unusual skin changes, change in the appearance/size of moles, unusual growths/lumps, swollen glands, night sweats, unexplained weight loss, signs of infection (e.g., fever, persistent sore throat).

Sirolimus is not recommended for the prevention of rejection of liver or lung transplants because it has infrequently caused very serious (possibly fatal) liver/lung problems in those cases.

Rapamune Oral Side Effects

See also Warning section.

Diarrhea, joint pain, shaking, acne, or trouble sleeping may occur. If any of these effects persist or worsen, notify your doctor promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

muscle pain/cramps
bone pain
increased thirst/hunger
frequent urination
vision changes
hearing problems (e.g., hearing loss, ringing in the ears)
unusual tiredness/weakness
fast/slow/irregular heartbeat
easy bruising/bleeding
mental/mood changes
swelling ankles/feet
severe headache
dizziness
stomach/abdominal pain

Tell your doctor immediately if any of these rare but very serious side effects occur:

change in the amount of urine
chest pain
shortness of breath
pain/redness/swelling of arms or legs
dark urine
yellowing eyes/skin
persistent nausea/vomiting

Sirolimus may slow wound healing after surgery. Tell your doctor immediately if you have signs that your surgery wound is not healing well (e.g., redness, swelling, pain). The risk of poor wound healing is higher if you are obese.

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