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Ponstel Oral

  • easy bruising/bleeding
  • signs of infection (e.g., fever, persistent sore throat)
  • unexplained stiff neck
  • change in the amount/color of urine


This drug may rarely cause serious, possibly fatal liver disease. If you notice any of the following rare but very serious side effects, stop taking mefenamic acid and consult your doctor or pharmacist immediately:

  • persistent nausea/vomiting
  • severe stomach/abdominal pain
  • extreme/unusual tiredness
  • weakness
  • dark urine
  • yellowing eyes/skin


A very serious allergic reaction to this drug is rare. However, stop taking mefenamic acid and immediately seek medical attention if you notice any of the following symptoms of a serious allergic reaction:

  • rash/blisters
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing


This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Ponstel Oral Precautions

Before taking mefenamic acid, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (e.g., ibuprofen, naproxen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs
  • severe kidney disease
  • recent heart bypass surgery (CABG)
  • active bleeding/sores in stomach/intestines (ulcer, gastrointestinal bleeding)


Before using this medication, tell your doctor or pharmacist your medical history, especially of:

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