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Butalbital-Aspirin-Caffeine Oral

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

  • ACE inhibitors (e.g., lisinopril, enalapril)
  • acetazolamide
  • adenosine
  • antacids
  • beta agonists (e.g., albuterol)
  • "blood thinners" (e.g., warfarin, heparin, ticlopidine)
  • certain drugs used to treat gout (e.g., uricosuric drugs such as probenecid, sulfinpyrazone)
  • certain antibiotics (e.g., penicillin, sulfonamides such as sulfamethoxazole)
  • diabetes drugs (e.g., sulfonylureas such as glyburide, insulin)
  • drugs affecting liver enzymes that remove this medication from your body (such as macrolide antibiotics including erythromycin, cimetidine, disulfiram, valproic acid, MAO inhibitors including furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine)
  • ginkgo biloba
  • lepirudin
  • lithium
  • 6-mercaptopurine
  • methotrexate
  • methoxyflurane
  • pemetrexed
  • phenytoin
  • salicylates (e.g., salsalate)
  • certain antidepressants (SSRIs such as fluoxetine, fluvoxamine)

This drug can speed up the removal of other drugs from your body by affecting certain liver enzymes. These affected drugs include cyclosporine, corticosteroids such as prednisone, estrogen, felodipine, metronidazole, quinidine, certain beta blockers such as metoprolol, theophylline, doxycycline.



Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone, amitriptyline, trazodone).

Check the labels on all your medicines (e.g., cough-and-cold products, other headache medications) because they may contain aspirin, caffeine, or drowsiness-causing ingredients. Also keep in mind that certain beverages (e.g., coffee, colas, tea) contain caffeine. Ask your pharmacist about using those products safely.

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