Vagifem Vagl

In Depth

undiagnosed abnormal vaginal bleeding
certain cancers (e.g., breast cancer, especially non-metastatic type)
current/history of blood clots
history of stroke or heart attack

Before using this medication, tell your doctor or pharmacist your medical history, especially of:

family medical history (especially breast lumps and cancer)
asthma
diabetes
seizures
migraine headaches
liver disease
heart disease (e.g., high blood pressure, congestive heart failure)
kidney disease
low thyroid hormone (hypothyroidism)
a certain hormone problem (hypoparathyroidism)
abnormal calcium level in the blood
depression
high blood pressure during pregnancy (toxemia)
yellowing of eyes and skin (cholestatic jaundice) during pregnancy or with past estrogen use
womb problems (e.g., uterine fibroids, endometriosis)
cholesterol or lipid problems
gallbladder disease
excessive weight gain
certain blood disorder (porphyria)

If you will be having surgery or will be confined to a chair or bed for a long period of time (e.g., a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking this drug.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

This drug may cause a patchy darkening of the skin on the face (melasma). Sunlight may intensify this darkening and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding use of sunscreens and protective clothing.

Cigarette smoking can increase the chance of blood clots while taking this medicine (especially in women over the age of 35).

This medication is not usually used in women of childbearing age. Therefore, it is unlikely to be used during pregnancy or breast-feeding. Consult your doctor if you have any questions about this medication.

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