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Zyrtec-D Oral

Generic Name: PSEUDOEPHEDRINE/CETIRIZINE EXTENDED-RELEASE - ORAL
Pronounced: (sue-doh-eff-ED-rin/seh-TEER-ah-zeen)

Zyrtec-D Oral Side Effects

Drowsiness, fatigue, dry mouth, dizziness, nervousness, nausea, headache, or trouble sleeping may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these serious side effects occur:

  • fast/irregular heartbeat
  • uncontrolled shaking or tremor


Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • yellowing eyes or skin
  • dark urine
  • persistent fatigue
  • mental/mood changes
  • seizures
  • trouble breathing
  • trouble urinating


A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include:

  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing


This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Zyrtec-D Oral Precautions

Before taking pseudoephedrine with cetirizine, tell your doctor or pharmacist if you are allergic to it; or to hydroxyzine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • glaucoma (narrow angle type)
  • severe difficulty urinating (urinary retention)
  • severe high blood pressure
  • severe heart/blood vessel disease (coronary artery disease)
  • experienced serious side effects with decongestants (e.g., irregular heart rhythm)
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