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Rifater Oral

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Generic Name: RIFAMPIN/ISONIAZID/PYRAZINAMIDE - ORAL
Pronounced: (riff-AM-pin/eye-so-NYE-uh-zid/pir-uh-ZIN-uh-mide)

Rifater Oral Warning

Isoniazid has rarely caused very serious (possibly fatal) liver disease. The risk of liver disease is increased in people who are 35 years and older, who use alcohol or illegal injection drugs, or who currently have long-term liver problems. Tell your doctor immediately if you develop symptoms of liver disease, including persistent nausea/vomiting, severe stomach/abdominal pain, unusual weakness/tiredness, dark urine, yellowing eyes/skin.

Your doctor should order liver function tests while you are taking this medication. Keep all medical and laboratory appointments.

Rifater Oral Side Effects

See also Warning section.

Nausea/vomiting, upset stomach, heartburn, mild muscle/joint pain, or headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

This medication may cause urine, sweat, saliva, or tears to turn reddish. This effect is harmless and will disappear when the medication is stopped. However, dentures and contact lenses may become permanently stained.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • numbness/tingling of arms/legs
  • painful/swollen joints


Tell your doctor immediately if any of these rare but serious side effects occur:

  • change in the amount of urine
  • increased thirst/urination
  • bloody urine
  • vision changes
  • fast heartbeat
  • easy bruising/bleeding
  • signs of a new infection (such as fever, persistent sore throat)
  • mental/mood changes (such as confusion, psychosis)
  • seizures


This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor immediately if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.

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