Isoniazid-Rifamp-Pyrazinamide Oral

Isoniazid-Rifamp-Pyrazinamide Oral Warning

Rarely, the isoniazid in this product has caused a severe (sometimes fatal) liver problem (hepatitis). Hepatitis can develop at any time while you are taking this medication. Immediately tell your doctor if you develop symptoms of liver problems (persistent nausea, vomiting, weakness, tiredness, stomach/abdominal pain, dark urine, yellowing eyes/skin). The risk of hepatitis increases with age (35 and older), persistent liver problems, and the use of alcohol and/or illegal injection drugs. Do not use alcohol or illegal injection drugs while taking this medication.

You will need certain blood tests (liver function tests) regularly to check for side effects. Keep all medical and laboratory appointments.

Isoniazid-Rifamp-Pyrazinamide Oral Side Effects

See also Warning section.

Tingling/numbness in the hands/feet, headache, aching joints, diarrhea, stomach upset/pain, or nausea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

• persistent nausea/vomiting
• weakness
• tiredness
• severe or persistent stomach/abdominal pain
• dark urine
• yellowing eyes/skin
• loss of appetite
• bloody/pink/cloudy urine
• painful/swollen joints
• swelling of hands/feet
• changes in skin color
• increase in the amount of urine
• breast enlargement in males

Tell your doctor immediately if any of these rare but very serious side effects occur:

• vision changes
• confusion
• seizures
• sudden weakness
• pale skin
• fast breathing
• easy bruising/bleeding
• new fever
• persistent sore throat
• chills

This medication may rarely cause a serious immune system problem (systemic lupus erythematosus). Tell your doctor immediately if you experience any of these unlikely but serious side effects:

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Drug Interactions