Margesic Oral

In Depth

Generic Name: PROPOXYPHENE - ORAL
Pronounced: (pro-POX-ee-feen)

Margesic Oral Warning

Propoxyphene has caused overdose (even death) when taken in large doses, either alone or with alcohol/drugs that can affect breathing or cause drowsiness (such as antidepressants, sedatives, muscle relaxants). Do not take this medication more often or use a larger dose than prescribed. Avoid alcoholic beverages.

Other medications can affect the removal of propoxyphene from your body, which may affect how propoxyphene works. Examples include nefazodone, St. John's wort, azole antifungals (such as itraconazole), HIV protease inhibitors (such as ritonavir), macrolide antibiotics (such as erythromycin), rifamycins (such as rifampin), among others. Before taking propoxyphene, tell your doctor or pharmacist of all the medications you may use.

Margesic Oral Side Effects

Nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, or headache may occur. Some of these side effects may decrease after you have been using this medication for a while. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To prevent constipation, eat a diet adequate in fiber, drink plenty of water, and exercise. Ask your pharmacist for help in selecting a laxative (such as a stimulant type with stool softener).

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

mental/mood changes (such as agitation, confusion, hallucinations)
severe stomach/abdominal pain
difficulty urinating

Get medical help right away if any of these rare but serious side effects occur:

fainting
seizure
slow/shallow breathing
unusual drowsiness/difficulty waking up

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:

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