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Rifadin IV

In Depth

Generic Name: RIFAMPIN - INJECTION
Pronounced: (riff-AM-pin)

Rifadin IV Side Effects

This drug may cause nausea, menstrual changes, headache, drowsiness, or dizziness. Redness, swelling, and pain at the injection site may occur. If any of these effects persist or worsen, inform your doctor promptly.

This medication may produce a harmless, reddish coloration of urine, sweat, saliva, or tears. Soft contact lenses may be permanently stained.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Rifampin may infrequently cause serious liver disease. Though sometimes necessary to completely treat certain infections, combination treatment with other drugs (e.g., isoniazid, pyrazinamide) may increase this risk. Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • flu-like symptoms (fever, chills, headache, muscle aches)
  • change in amount of urine
  • persistent nausea/vomiting
  • stomach/abdominal pain
  • dark urine
  • yellowing eyes/skin
  • mental/mood changes (e.g., confusion, unusual behavior)
  • unusual tiredness
  • easy bruising/bleeding
  • small red spots on the skin
  • joint pain/swelling


This medication may rarely cause a severe intestinal condition (pseudomembranous colitis) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor immediately if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection (oral/vaginal fungal infection). Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include:

  • rash
  • itching
  • swelling
  • severe dizziness
  • trouble breathing


This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

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