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Vivelle TD

Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • mental/mood changes (e.g., severe depression, memory loss)
  • vision changes (e.g., change in contact lens fit, loss of vision)
  • swelling of hands or feet
  • stomach/abdominal/pelvic pain
  • vomiting
  • breast lumps
  • unusual vaginal bleeding (e.g., spotting, breakthrough bleeding, prolonged/recurrent bleeding)
  • unusual vaginal discharge/itching/odor
  • yellowing of the eyes or skin


Seek immediate medical attention if any of these unlikely but serious side effects occur:

  • calf pain/swelling
  • sudden severe headache
  • chest pain
  • trouble breathing
  • weakness on one side of the body
  • slurred speech


A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include:

  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing


This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Vivelle TD Precautions

Before using estradiol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • undiagnosed abnormal vaginal bleeding
  • certain cancers (e.g., breast cancer, especially non-metastatic type)
  • current/history of blood clots
  • history of stroke or heart attack
  • liver disease


Before using this medication, tell your doctor or pharmacist your medical history, especially of:

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