Per-Trip Oral

In Depth

sudden mental/mood changes (such as confusion, hallucinations)
unexplained fever
fast heartbeat
increased sweating
widened pupils
muscle stiffness/twitching
loss of coordination
severe nausea/vomiting/diarrhea

Seek immediate medical attention if any of these rare but very serious side effects occur:

signs of stroke (such as weakness on one side of the body, slurred speech, sudden vision changes, confusion)
signs of pneumonia from aspiration (such as cough, fever, trouble breathing)
chest/jaw/left arm pain
severe dizziness/fainting
fast/irregular heartbeat
black stools
vomit that looks like coffee grounds
seizures

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including:

rash
itching/swelling (especially of the face/tongue/throat)
severe dizziness
trouble breathing

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Per-Trip Oral Precautions

See also Warning section.

Before taking amitriptyline with perphenazine, tell your doctor or pharmacist if you are allergic to it; or to other tricyclic antidepressants (such as nortriptyline); or to other phenothiazines (such as chlorpromazine, fluphenazine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of:

bleeding problems
decreased bone marrow function
breathing problems (such as asthma, emphysema)
liver problems
low blood pressure
recent heart attack
breast cancer
problems urinating (such as due to enlarged prostate)
overactive thyroid (hyperthyroidism)
a certain eye problem (glaucoma)
personal or family history of bipolar disorder
alcohol/substance abuse
family history of suicide
seizures
diabetes
conditions that may increase your risk of seizures (such as head injury, drug/alcohol withdrawal)
a certain severe reaction to other medications (neuroleptic malignant syndrome)
a certain adrenal gland tumor (pheochromocytoma)
restless legs syndrome
Parkinson's disease