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Etrafon 2-10 Oral

To relieve dry mouth, suck on hard candy or ice chips, chew gum, drink water, or use a saliva substitute.

Perphenazine may cause muscle/nervous system problems (extrapyramidal symptoms-EPS). Your doctor may prescribe another medication to decrease these side effects. Tell your doctor immediately if you notice any of the following side effects:

  • drooling/trouble swallowing
  • mask-like expression of the face
  • restlessness/constant need to move
  • shaking (tremor)
  • shuffling walk
  • stiff muscles
  • severe muscle spasms/cramping (such as twisting neck, arching back, eyes rolling up)


Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • easy bruising/bleeding
  • signs of infection (such as fever, persistent sore throat)
  • severe stomach/abdominal pain
  • persistent nausea/vomiting
  • dark urine
  • yellowing eyes/skin
  • persistent heartburn


Perphenazine may cause a condition known as tardive dyskinesia. In some cases, this condition may be permanent. Tell your doctor immediately if you develop any uncontrollable movements such as lip smacking, mouth puckering, tongue thrusting, chewing, or unusual arm/leg movements.

In rare cases, perphenazine may increase your level of a certain substance made by the body (prolactin). For females, this increase in prolactin may result in unwanted breast milk, missed/stopped periods, or difficulty becoming pregnant. For males, it may result in decreased sexual ability, inability to produce sperm, or enlarged breasts. If you develop any of these symptoms, tell your doctor immediately.

This medication may rarely cause a very serious condition called serotonin syndrome. The risk increases when this medication is used with certain other drugs (see Drug Interactions section). This medication may also cause a rare serious condition called neuroleptic malignant syndrome (NMS). These 2 conditions can have some of the same symptoms. Seek immediate medical attention if you develop any of the following symptoms:

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