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Zofran IV

Generic Name: ONDANSETRON - INJECTION
Pronounced: (on-DANS-eh-tron)

Zofran IV Side Effects

Headache, fever, lightheadedness, dizziness, drowsiness, tiredness, constipation, or redness/pain/burning at the injection site may occur. If these effects persist or worsen, notify your doctor promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including:

  • stomach pain
  • muscle stiffness/spasm
  • vision changes (e.g., temporary loss of vision, blurred vision, uncontrollable eye movements)


Get medical help right away if any of these rare but very serious side effects occur:

  • chest pain
  • fainting
  • slow/fast/irregular heartbeat


A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction:

  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing


This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Zofran IV Precautions

Before using ondansetron, tell your doctor or pharmacist if you are allergic to it; or to other serotonin blockers (e.g., granisetron); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of:

  • irregular heartbeat
  • liver disease
  • stomach/intestinal problems (e.g., recent abdominal surgery, ileus, swelling)
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