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Moduretic Oral

Generic Name: AMILORIDE/HYDROCHLOROTHIAZIDE - ORAL
Pronounced: (a-MIL-oh-ride/HYE-droe-KLOR-oh-THYE-a-zide)

Moduretic Oral Interactions

Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medication because very serious interactions may occur:

  • dofetilide


If you are currently using this medication listed above, tell your doctor or pharmacist before starting this product.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

  • alcohol
  • cisapride
  • drugs that may lower your blood pressure (e.g., barbiturates such as phenobarbital, guanethidine, methyldopa, narcotic pain relievers such as codeine)
  • drugs for diabetes (e.g., glyburide, insulin)
  • diazoxide
  • digoxin
  • drugs that may be harmful to your kidneys (e.g., cyclosporine)
  • lithium
  • probenecid
  • tacrolimus
  • tubocurarine
  • drugs whose removal from the body is affected by acid levels of urine (e.g., amphetamine, methenamine, quinidine)
  • other products that may decrease potassium levels (e.g., amphotericin B, corticotropin, corticosteroids including prednisone)
  • other products that may increase potassium levels (e.g., eplerenone, spironolactone, triamterene, potassium supplements, salt substitutes containing potassium, ACE inhibitors including benazepril and captopril, angiotensin receptor antagonists including losartan and valsartan)


Cholestyramine and colestipol may decrease the absorption of this medication. If you are taking either of these drugs, separate them from this medication by at least 4 hours.

Check the labels on all your medicines (e.g., cough-and-cold products, diet aids, nonsteroidal anti-inflammatory drugs-NSAIDs for pain/fever reduction) because they may contain ingredients that could increase your blood pressure (e.g., pseudoephedrine, phenylephrine, chlorpheniramine, diphenhydramine, clemastine, ibuprofen, naproxen). Ask your pharmacist about using those products safely.

This product can affect the results of certain lab tests (glucose tolerance testing, parathyroid test). Make sure laboratory personnel and all your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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