Methotrexate (Anti-Rheumatic) Oral

Methotrexate (Anti-Rheumatic) Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

See also Warnings about non-steroidal anti-inflammatory drugs (NSAIDs) and aspirin use.

This drug should not be used with the following medications because very serious interactions may occur:

• acitretin
• asparaginase
• live vaccines
• natalizumab
• pyrimethamine

If you are currently using any of these medications, tell your doctor or pharmacist before starting methotrexate.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of:

• other cancer treatments potentially toxic to the kidney (e.g., cisplatin)
• ciprofloxacin
• digoxin
• leflunomide
• other drugs potentially toxic to the liver (e.g., azathioprine, sulfasalazine, retinoids such as isotretinoin)
• penicillins
• phenytoin
• probenecid
• procarbazine
• sulfa medications
• theophylline

Certain antibiotics (e.g., chloramphenicol, sulfa, tetracyclines) may interfere with methotrexate blood tests (increase methotrexate blood levels due to protein-binding displacement). Make sure laboratory personnel and your doctors know you are using any of these types of antibiotics.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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