Saquinavir Oral

In Depth

Generic Name: SAQUINAVIR SOFTGEL CAPSULE - ORAL
Pronounced: (sah-KWIN-uh-veer)

Saquinavir Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious interactions may occur:

artemether-lumefantrine
certain benzodiazepines (midazolam, triazolam)
bepridil
cisapride
certain drugs for irregular heartbeat (amiodarone, flecainide, propafenone, quinidine)
ergot alkaloids (e.g., dihydroergotamine, ergonovine, ergotamine, methylergonovine)
garlic capsules
pimozide
ranolazine
rifampin
certain "statin" cholesterol drugs (simvastatin, lovastatin)
St Johns wort

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting saquinavir.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

certain anti-seizure drugs (carbamazepine, phenytoin, phenobarbital)
atorvastatin
certain calcium channel blockers (e.g., nifedipine, felodipine, nicardipine)
certain azole fungal medications (ketoconazole, itraconazole)
certain benzodiazepines (alprazolam, diazepam, flurazepam, clorazepate)
certain cancer drugs (sunitinib, lapatinib, dasatinib)
clarithromycin
delavirdine
dexamethasone
digoxin
drugs for male sexual function problems (sildenafil, tadalafil, vardenafil)
certain drugs that weaken the immune system (cyclosporine, tacrolimus, sirolimus)
efavirenz
eplerenone
ethinyl estradiol
certain other HIV protease inhibitors (atazanavir, darunavir, indinavir, nelfinavir, ritonavir, lopinavir/ritonavir)
lidocaine
loperamide
methadone
nevirapine
ranitidine
rifabutin
temsirolimus
tricyclic antidepressants (e.g., amitriptyline, imipramine)
warfarin

If any of these medications are taken with saquinavir, your doctor may change your dose of saquinavir or the other drug(s), or your doctor may monitor you specially. Consult your doctor or pharmacist for more details.

This medication may decrease the effectiveness of some birth control pills. This can result in pregnancy. However, to reduce the risk of spreading HIV to others, always use barrier protections during all sexual activity. (See also Notes section.)

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.