Desipramine Oral

In Depth

Other drugs besides desipramine which may affect the heart rhythm (QTc prolongation in the EKG) include amiodarone, dofetilide, erythromycin, procainamide, sotalol, and sparfloxacin, among others. QTc prolongation can infrequently result in serious, rarely fatal irregular heartbeat. Consult your doctor or pharmacist for more details and for instructions on how you may decrease the risk of this effect.

Also report the use of drugs which might increase seizure risk (decrease seizure threshold) when combined with this medication such as bupropion, isoniazid (INH), theophylline, or tramadol, among others. Consult your doctor or pharmacist for details.

Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-anxiety drugs (e.g., diazepam), anti-seizure drugs (e.g., levetiracetam), drugs for motion sickness (e.g., meclizine).

Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-containing ingredients or decongestants that could increase your heart rate or blood pressure. Ask your pharmacist about the safe use of those products.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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