Ranolazine Oral
In Depth
- Uses and How to Use
- Dosage and Storage
- Precautions and Side Effects
- Drug Interactions
- Drug Images
Pronounced: (ra-NOE-la-zeen)
Ranolazine Oral Interactions
Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.
This drug should not be used with the following medications because very serious interactions may occur:
- drugs affecting liver enzymes that remove ranolazine from your body (azole antifungals such as itraconazole/ketoconazole, macrolide antibiotics such as erythromycin, protease inhibitors such as ritonavir, diltiazem, verapamil)
- drugs which may affect the heart rhythm (QTc prolonging drugs such as dofetilide, quinidine, sotalol, thioridazine, ziprasidone)
If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting ranolazine.
Other drugs besides ranolazine and those listed above which may affect the heart rhythm (QTc prolongation in the EKG) include amiodarone, pimozide, procainamide, and sparfloxacin, among others. QTc prolongation can infrequently result in serious, rarely fatal irregular heartbeats. Consult your doctor or pharmacist for more details, and for instructions on how you may minimize the risk of this effect.
Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:
- cyclosporine
- drugs removed from your body by certain liver enzymes (e.g., digoxin, simvastatin, TCA antidepressants such as amitriptyline/imipramine, trazodone, certain antipsychotics such as clozapine/haloperidol/risperidone)
- drugs that may decrease potassium levels (e.g., "water pills"/diuretics such as furosemide/hydrochlorothiazide)
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
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