Nortriptyline Oral

In Depth

If you have been taking fluoxetine, wait at least 5 weeks before starting nortriptyline.

Cigarette smoking decreases blood levels of this medication. Tell your doctor if you smoke or if you have recently stopped smoking.

Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as:

certain antihistamines (e.g., diphenhydramine)
anti-seizure drugs (e.g., phenytoin, carbamazepine)
medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem)
muscle relaxants
narcotic pain relievers (e.g., codeine)
psychiatric medicines (e.g., fluphenazine, risperidone, trazodone)

Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products.

Also report the use of drugs which might increase seizure risk (decrease seizure threshold) when combined with nortriptyline (e.g., bupropion, isoniazid (INH), theophylline, tramadol, among others). Consult your doctor or pharmacist for details.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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