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Xedec Oral

Generic Name: GUAIFENESIN/PHENYLEPHRINE SUSTAINED-RELEASE - ORAL
Pronounced: (gweye-FEN-eh-sin/fen-ill-EFF-rin)

Xedec Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

This drug should not be used with the following medications because very serious interactions may occur:



  • MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine)


If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting this medication.

Avoid taking MAO inhibitors within 2 weeks before, during, and after treatment with this medication. In some cases a serious (possibly fatal) drug interaction may occur.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

  • tricyclic antidepressants (e.g., amitriptyline)
  • beta blockers (e.g., metoprolol, propranolol)
  • digoxin
  • guanethidine
  • methyldopa
  • reserpine


Guaifenesin and phenylephrine are available in both prescription and nonprescription products. Check the labels of all your medications to make sure you are not taking more than one product containing guaifenesin or phenylephrine.

Guaifenesin can affect the results of certain lab tests (e.g., urine levels of certain acids). Make sure laboratory personnel and all your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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