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Zelapar Oral

Generic Name: SELEGILINE RAPIDLY DISSOLVING TABLET - ORAL
Pronounced: (seh-LEDGE-uh-leen)

Zelapar Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious (possibly fatal) interactions may occur:



  • antidepressants (e.g., TCAs such as amitriptyline/protriptyline, nefazodone, SSRIs such as fluoxetine/paroxetine/sertraline, venlafaxine)
  • appetite suppressants (e.g., diethylpropion, sibutramine)
  • drugs for attention deficit disorder (e.g., atomoxetine, methylphenidate)
  • certain antihistamines (azatadine, carbetapentane, chlorpheniramine)
  • bronchodilators (e.g., albuterol, salmeterol)
  • bupropion
  • buspirone
  • cyclobenzaprine
  • dextromethorphan
  • certain drugs for glaucoma (e.g., apraclonidine, brimonidine)
  • certain drugs for high blood pressure (e.g., guanethidine, methyldopa)
  • other MAO inhibitors (furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, tranylcypromine)
  • nasal decongestants (e.g., phenylephrine, pseudoephedrine)
  • certain narcotic medications (e.g., meperidine, methadone, propoxyphene, fentanyl)
  • street drugs (e.g., MDMA/"ecstasy," LSD, mescaline)
  • stimulants (e.g., amphetamines, ephedrine, epinephrine, phenylalanine)
  • "triptan" migraine drugs (e.g., sumatriptan, rizatriptan)
  • tramadol
  • tyrosine
  • tryptophan


If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting selegiline. Do not take these medications within the 2 weeks before, during, or after treatment with selegiline. If you have been taking fluoxetine, wait at least 5 weeks before starting selegiline. Discuss with your doctor how much time to wait between starting or stopping any of these drugs and taking selegiline.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

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