Sk-Phenobarbital Oral

In Depth

Generic Name: PHENOBARBITAL - ORAL
Pronounced: (fee-no-BARB-ih-tall)

Sk-Phenobarbital Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

This drug should not be used with the following medications because very serious interactions may occur:

darunavir
delavirdine
etravirine
sodium oxybate
voriconazole

Some other drowsiness-causing medications may cause serious (possibly fatal) slowed breathing when taken with higher doses of phenobarbital. Tell your doctor or pharmacist if you also take other drugs that cause drowsiness such as:

medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem)
muscle relaxants
narcotic pain relievers (e.g., codeine)
psychiatric medicines (e.g., chlorpromazine, risperidone, amitriptyline, trazodone)

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting phenobarbital.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

warfarin
estrogens
erlotinib
corticosteroids (e.g., prednisone, dexamethasone)
quinidine
felodipine
irinotecan
metronidazole
doxycycline
certain antifungal medications (griseofulvin, posaconazole)
phenytoin
valproic acid
telithromycin
theophylline
MAO inhibitors (e.g., phenelzine, selegiline)

This medication can speed up the removal of many other drugs from your body by affecting certain liver enzymes. This can affect how well these other drugs work. Tell your doctor or pharmacist of all other drugs you take.

Before using this medication, tell your doctor or pharmacist if you use any other prescription and nonprescription products that cause drowsiness such as certain antihistamines (e.g., diphenhydramine) and anti-seizure drugs (e.g., carbamazepine).

Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about using those products safely.

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