APOKYN SubQ

APOKYN SubQ Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

This drug should not be used with the following medications because very serious interactions may occur:

• certain drugs for nausea/bowel problems (5HT-3 antagonists such as alosetron, granisetron, ondansetron)

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting apomorphine.

Apomorphine may affect the heartbeat when used at higher doses. Many drugs besides apomorphine may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin), among others. Therefore, before using apomorphine, report all medications you are currently using to your doctor or pharmacist. .

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

• antipsychotics (e.g., chlorpromazine, haloperidol, thiothixene)
• certain drugs for nausea (e.g., metoclopramide, phenothiazines such as prochlorperazine)
• drugs for high blood pressure (e.g., beta blockers such as atenolol)
• vasodilators (e.g., nitrates)
• "water pills" (diuretics such as furosemide, thiazides)

Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., risperidone, amitriptyline, trazodone). Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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Precautions and Side Effects