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Nembutal Sodium Inj

Generic Name: PENTOBARBITAL - INJECTION
Pronounced: (pen-toe-BAR-bi-tal)

Nembutal Sodium Inj Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. This drug should not be used with the following medications because very serious interactions may occur:

  • sodium oxybate
  • delavirdine
  • darunavir
  • voriconazole


Some other drowsiness-causing medications may cause serious (possibly fatal) slowed breathing when taken with higher doses of pentobarbital. Tell your doctor or pharmacist if you also take other drugs that cause drowsiness such as:

  • medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem)
  • muscle relaxants (e.g., methocarbamol)
  • narcotic pain relievers (e.g., codeine)
  • psychiatric medicines (e.g., chlorpromazine, risperidone, amitriptyline, trazodone)


If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting pentobarbital.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

  • warfarin
  • estrogens (e.g., some birth control pills/hormone replacement treatments)
  • corticosteroids (e.g., prednisone, dexamethasone)
  • quinidine
  • felodipine
  • certain beta blockers (acebutolol, betaxolol, carteolol, metoprolol, propranolol)
  • metronidazole
  • doxycycline
  • griseofulvin
  • phenytoin
  • valproic acid
  • cyclosporine
  • sunitinib
  • dasatinib
  • erlotinib
  • telithromycin
  • theophylline
  • MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine)


Before using this medication, tell your doctor or pharmacist if you use any other prescription and nonprescription products that cause drowsiness such as certain antihistamines (e.g., diphenhydramine) and anti-seizure drugs (e.g., carbamazepine).

Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about using those products safely.

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