Tykerb Oral

Tykerb Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

• drugs affecting liver enzymes that remove lapatinib from your body (such as dexamethasone, cimetidine, St. John's wort, azole antifungals including itraconazole/ketoconazole, macrolide antibiotics including erythromycin/clarithromycin, HIV protease inhibitors including ritonavir/saquinavir, rifamycins including rifabutin, certain anti-seizure medicines including carbamazepine/phenytoin)

This drug can slow down the removal of other drugs from your body by affecting certain liver enzymes. These affected drugs include certain "statin" cholesterol medications (simvastatin, lovastatin, atorvastatin), tacrolimus, trazodone, digoxin, and cyclosporine, among others. Tell your doctor if you also take any of these medications.

Many drugs besides lapatinib may affect the heart rhythm (QT prolongation), including dofetilide, pimozide, procainamide, amiodarone, quinidine, sotalol, macrolide antibiotics (such as erythromycin), among others. Therefore, before using lapatinib, report all medications you are currently using to your doctor or pharmacist.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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Precautions and Side Effects