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Pylera Oral

Generic Name: BISMUTH SUBCITRATE/METRONIDAZOLE/TETRACYCLINE - ORAL
Pronounced: (BIZ-muth sub-SIT-rate/meh-troh-NID-uh-zole/teh-truh-SYE-kleen)

Pylera Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious interactions may occur:

  • acitretin
  • amprenavir solution taken by mouth
  • isotretinoin
  • strontium
  • tretinoin taken by mouth


Avoid disulfiram for 2 weeks before and during treatment with this medication.

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting this product.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

  • atovaquone
  • "blood thinners" (e.g., warfarin, heparin)
  • busulfan
  • digoxin
  • drugs affecting liver enzymes that remove metronidazole from your body (such as cimetidine, certain anti-seizure medicines including phenytoin, phenobarbital)
  • fluorouracil
  • lithium
  • live bacterial vaccines (e.g., typhoid vaccine)
  • methoxyflurane
  • penicillins (e.g., amoxicillin, dicloxacillin)
  • tretinoin applied to the skin


This medication may decrease the effectiveness of combination-type birth control pills. This effect can result in pregnancy. Ask your doctor or pharmacist for details. Discuss whether you should use additional reliable birth control methods while taking this product. See also Precautions section.

This product may interfere with certain laboratory tests (including liver function tests, triglycerides, hexokinase glucose, lactate dehydrogenase), possibly causing false test results. This product may also interfere with X-ray exams of the stomach/intestines. Make sure laboratory personnel and all your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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