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Venlafaxine Oral

Generic Name: VENLAFAXINE SUSTAINED-RELEASE - ORAL
Pronounced: (ven-luh-FAX-een)

Venlafaxine Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Taking certain medications with this product could result in serious (rarely fatal) drug interactions. Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) with venlafaxine for 2 weeks before treatment, during treatment, and at least 7 days after your last dose of venlafaxine. Consult your doctor or pharmacist for more information.

This drug should also not be used with the following medications because very serious (possibly fatal) interactions may occur:

  • weight loss drugs (e.g., sibutramine, phentermine)
  • tryptophan


If you are currently using any of these medications, tell your doctor or pharmacist before starting venlafaxine.

Many drugs besides venlafaxine may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin), thioridazine, among others. Therefore, before using venlafaxine, report all medications you are currently using to your doctor or pharmacist.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

  • drugs removed from your body by certain liver enzymes (e.g., antipsychotics such as clozapine/ haloperidol, HIV medications such as indinavir, tricyclic antidepressants-TCAs such as desipramine)
  • drugs affecting liver enzymes that remove venlafaxine from your body (e.g., cimetidine, azole antifungals such as ketoconazole, itraconazole)
  • drugs that can cause bleeding/bruising (e.g., aspirin, antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen, "blood thinners" such as heparin/warfarin)
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