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SYMBYAX Oral

Generic Name: OLANZAPINE/FLUOXETINE - ORAL
Pronounced: (oh-LAN-zuh-peen/flew-OX-eh-teen)

SYMBYAX Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Fluoxetine (one of the drugs in this medication) can stay in your body for many weeks after your last dose and may interact with many other medications. If you have taken this medication in the previous 5 weeks, consult your doctor or pharmacist before using any other medication.

Certain medications could result in serious (rarely fatal) drug interactions if taken with this product. Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) for 2 weeks before treatment, during treatment, and at least 5 weeks after treatment with this medication. Consult your doctor or pharmacist for more information.

The following medications should not be used with this product or for 5 weeks after your last dose because very serious (possibly fatal) interactions may occur:

  • pimozide
  • sibutramine
  • thioridazine


If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting this medication.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

  • drugs removed from your body by certain liver enzymes (e.g., carbamazepine, cimetidine, phenytoin, vinblastine, drugs for anxiety such as alprazolam and diazepam, antipsychotics such as aripiprazole/clozapine/haloperidol/perphenazine, antiarrhythmics such as propafenone/flecainide, TCA antidepressants such as desipramine/imipramine)
  • fosamprenavir/ritonavir
  • metoprolol
  • "water pills" (diuretics such as furosemide)
  • drugs that can cause bleeding/bruising (e.g., aspirin, antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen, "blood thinners" such as heparin, warfarin)
  • drugs for high blood pressure
  • medicines for Parkinson's disease (e.g., levodopa, cabergoline)
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