St. John's Wort Oral
In Depth
- Uses and How to Use
- Dosage and Storage
- Precautions and Side Effects
- Drug Interactions
- Drug Images
St. John's Wort Oral Interactions
Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) within 2 weeks before, during, and after using St. John's wort. In some cases a serious (possibly fatal) drug interaction may occur.
St. John's wort interacts with many medications and products. The following drugs are just some of the products that may interact with St. John's wort.
Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:
- drugs used to prevent organ rejection (e.g., cyclosporine, sirolimus, tacrolimus)
- drugs used to treat cancer (e.g., cyclophosphamide, etoposide, irinotecan, paclitaxel, tamoxifen)
- heart medications (e.g., digoxin, beta blockers such as metoprolol, calcium channel blockers such as diltiazem)
- anti-seizure drugs (e.g., carbamazepine, phenytoin, phenobarbital)
- tricyclic antidepressants (e.g., amitriptyline, nortriptyline)
- sympathomimetic drugs (e.g., albuterol, phenylephrine)
- drugs used to treat HIV infection such as protease inhibitors (e.g., indinavir), non-nucleoside reverse transcriptase inhibitors (NNRTIs such as delavirdine, efavirenz, nevirapine, etravirine), and entry inhibitors (e.g., maraviroc)
- drugs that can cause bleeding/bruising (e.g., antiplatelet drugs such as clopidogrel, "blood thinners" such as warfarin and heparin, NSAIDs such as ibuprofen)
Also tell your doctor if you take any other products/drugs that increase serotonin, such as bromocriptine, buspirone, dextromethorphan, meperidine, propoxyphene, phentermine, ergots such as dihydroergotamine, street drugs such as MDMA/"ecstasy," amphetamine. (See also Side Effects section.)
Aspirin can increase the risk of bleeding when used with this product. If your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Discuss the risks and benefits with your doctor.
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