Orap Oral
In Depth
- Uses and How to Use
- Dosage and Storage
- Precautions and Side Effects
- Drug Interactions
- Drug Images
Pronounced: (PIM-oh-zide)
Orap Oral Interactions
Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.
This drug should not be used with the following medications because very serious interactions may occur:
- aprepitant
- azole antifungals (e.g., itraconazole, ketoconazole, posaconazole, voriconazole)
- ciprofloxacin
- cisapride
- conivaptan
- delavirdine
- efavirenz
- fluvoxamine
- fosaprepitant
- certain medications for heart rhythm problems (e.g., antiarrhythmics such as amiodarone, ibutilide, sotalol, dofetilide, propafenone, quinidine)
- macrolide antibiotics (e.g., clarithromycin, erythromycin)
- nefazodone
- protease inhibitors (e.g., ritonavir, nelfinavir)
- paroxetine
- ranolazine
- sertraline
- sibutramine
- zileuton
When given with pimozide, these drugs may affect the heart rhythm (QT prolongation on the EKG). If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting pimozide.
Other drugs besides pimozide and those listed above that may affect the heart rhythm (QT prolongation in the EKG) include antibiotics (e.g., gatifloxacin, moxifloxacin), anti-nausea medications (e.g., dolasetron, granisetron), phenothiazines (e.g., chlorpromazine, thioridazine), tacrolimus, and ziprasidone, among others. Before using pimozide, report all medications you are currently using to your doctor or pharmacist. QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (e.g., severe dizziness, fainting) that require immediate medical attention. Ask your doctor or pharmacist for more details and for instructions on how you may reduce the risk of this effect.
Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:
- certain anticholinergic medications (e.g., dicyclomine, oxybutynin)
- anti-seizure medications (e.g., lamotrigine, phenytoin)
- drugs affecting liver enzymes that remove pimozide from your body (e.g., fluoxetine, carbamazepine)
- drugs used for Parkinson's disease (e.g., levodopa, pergolide, selegiline)
- certain "water pills" (potassium-wasting diuretics such as furosemide, hydrochlorothiazide)
Previous Section
