Factive Oral

In Depth

Generic Name: GEMIFLOXACIN - ORAL
Pronounced: (jem-ih-FLOX-uh-sin)

Factive Oral Interactions

See also the How to Use section.

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious interactions may occur:

strontium
certain drugs that affect the heart rhythm (antiarrhythmics that may cause QT prolongation such as amiodarone, dofetilide, quinidine, procainamide, sotalol)

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting gemifloxacin.

Other drugs besides gemifloxacin and those listed above that may affect the heart rhythm (QT prolongation in the EKG) include certain macrolide antibiotics (e.g., erythromycin, clarithromycin), and certain antipsychotic medications (e.g., pimozide, thioridazine, ziprasidone), among others. QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (e.g., severe dizziness, fainting) that require immediate medical treatment. Ask your doctor or pharmacist for more details and for instructions on how you may reduce the risk of this effect.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

live bacterial vaccines (e.g., typhoid, BCG)
corticosteroids (e.g., prednisone, hydrocortisone)
drugs for diabetes (e.g., glyburide, insulin)
female hormone replacement (e.g., estrogen, ethinyl estradiol)
nonsteroidal anti-inflammatory drugs (NSAIDs such as ibuprofen, naproxen)
certain "water pills" (potassium-wasting diuretics such as furosemide, hydrochlorothiazide)
probenecid
"blood thinners" (e.g., warfarin)
urinary alkalinizers (e.g., potassium/sodium citrate)

Also report the use of drugs that might increase seizure risk when combined with this medication such as isoniazid (INH), phenothiazines (e.g., chlorpromazine), theophylline, or tricyclic antidepressants (e.g., amitriptyline), among others. Consult your doctor or pharmacist for details.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.