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Chemergan VC with Codeine Oral

Generic Name: PROMETHAZINE/PHENYLEPHRINE/CODEINE - ORAL
Pronounced: (pro-METH-uh-zeen/fen-ill-EFF-rin AND KO-deen)

Chemergan VC with Codeine Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

This drug should not be used with the following medications because very serious interactions may occur:

  • epinephrine for low blood pressure
  • MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine)
  • metrizamide
  • sibutramine


If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting this medication. Avoid taking MAO inhibitors for 2 weeks before, during, and 2 weeks after treatment with this medication. In some cases a serious (possibly fatal) drug interaction may occur.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

  • anticholinergic drugs (e.g., benztropine, belladonna alkaloids)
  • cancer chemotherapy (e.g., methotrexate)
  • certain inhaled anesthetics (e.g., halothane)
  • cimetidine
  • guanethidine
  • guanadrel
  • methyldopa
  • narcotic antagonists (e.g., naltrexone, naloxone)
  • quinidine
  • reserpine


Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as:

  • certain antihistamines (e.g., diphenhydramine)
  • anti-seizure drugs (e.g., carbamazepine)
  • medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem)
  • muscle relaxants
  • narcotic pain relievers (e.g., codeine)
  • psychiatric medicines (e.g., chlorpromazine, risperidone, trazodone)


Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Also report the use of drugs that might increase seizure risk when combined with this medication such as isoniazid (INH), phenothiazines (e.g., thioridazine), theophylline, or tricyclic antidepressants (e.g., amitriptyline), among others. Consult your doctor or pharmacist for details.

This medication may interfere with certain laboratory tests (e.g., some pregnancy tests, blood sugar tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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