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Depo-Provera IM

Generic Name: MEDROXYPROGESTERONE ACETATE (ANTICANCER AGENT) - INJECTION
Pronounced: (meh-DROX-ee-pro-JESS-tur-own A-seh-tate)

Depo-Provera IM Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

This drug should not be used with the following medications because very serious interactions may occur:

  • amprenavir
  • sodium tetradecyl sulfate


If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting medroxyprogesterone.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

  • acitretin
  • aminoglutethimide
  • anticonvulsants (e.g., phenytoin)
  • corticosteroids (e.g., hydrocortisone, prednisone)
  • isotretinoin
  • troleandomycin
  • warfarin


Certain drugs can decrease the amount of medroxyprogesterone in your system. These drugs include aprepitant, bexarotene, bosentan, dapsone, felbamate, griseofulvin, certain HIV protease inhibitors (e.g., indinavir, nelfinavir, ritonavir, zidovudine), nevirapine, modafinil, phenylbutazone, rifamycins (e.g., rifampin), many seizure medications (e.g., barbiturates, carbamazepine, topiramate), St. John's wort. Consult your doctor or pharmacist for details, and tell your doctor or pharmacist if you are taking any of the drugs listed above.

This medication may interfere with certain laboratory tests (including certain hormone levels, thyroid tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you are using this medication.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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