Prazosin-Polythiazide Oral

Prazosin-Polythiazide Oral Interactions

Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medication because a very serious interaction may occur:

• cisapride

If you are currently using this medication, tell your doctor or pharmacist before starting prazosin/polythiazide. Consult your doctor or pharmacist if you have any questions.

Cholestyramine and colestipol can decrease the absorption of this medication. If you are taking any of these drugs, separate them from this medication by at least 4 hours.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

• anesthesia drugs
• barbiturates (e.g., phenobarbital)
• drugs for diabetes (e.g., glipizide, glyburide, metformin)
• diazoxide
• digoxin
• guanethidine
• beta blockers (e.g., atenolol)
• verapamil
• lithium
• methyldopa
• probenecid
• tubocurarine
• drugs that affect uric acid levels (e.g., probenecid, sulfinpyrazone)
• drugs that may cause potassium loss (e.g., amphotericin B, corticotropin, corticosteroids including prednisone)
• drugs whose removal from the body is affected by acid levels in the urine (e.g., amphetamine, methenamine, quinidine)
• drugs for sexual function problems (e.g., sildenafil, tadalafil, vardenafil)

If you are taking sildenafil at doses greater than 25 milligrams, you can decrease your risk of fainting by taking sildenafil at least four hours apart from your prazosin/polythiazide. Consult your doctor or pharmacist if you have any questions.

Tell your doctor or pharmacist if you also take drugs that can cause drowsiness, lower your blood pressure, or make it difficult for you to urinate such as:

• certain antihistamines (e.g., diphenhydramine)
• anti-anxiety drugs (e.g., diazepam)
• anti-seizure drugs (e.g., carbamazepine)
• medicine for sleep (e.g., zolpidem, temazepam)
• muscle relaxants (e.g., carisoprodol)
• narcotic pain relievers (e.g., codeine)
• psychiatric medicines (e.g., phenothiazines such as chlorpromazine or tricyclic antidepressants such as amitriptyline)
• tranquilizers

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Precautions and Side Effects