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Synthrox Oral

Generic Name: LEVOTHYROXINE - ORAL
Pronounced: (lee-voe-thye-ROX-een)

Synthrox Oral Interactions

Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription drugs you may use, especially of:

  • warfarin
  • digoxin
  • estrogen products (including estrogen-containing birth control pills)
  • diabetes medicines (e.g., insulin, glipizide, rosiglitazone)
  • amiodarone
  • iodide (including radiographic contrast agents containing iodine)
  • lithium
  • anti-thyroid agents (e.g., methimazole, propylthiouracil)
  • androgens/anabolic steroids
  • glucocorticoids (e.g., dexamethasone, prednisone)
  • high dose salicylates (e.g., aspirin)
  • phenobarbital
  • rifamycins (e.g., rifampin)
  • beta blockers (e.g., propranolol)
  • antidepressants (e.g., amitriptyline, maprotiline, sertraline)
  • cytokines (e.g., interferon-alpha, interleukin-2)
  • growth hormones
  • ketamine
  • theophylline


Check the labels on all your medicines (e.g., cough-and-cold products, diet aids) because they may contain ingredients such as decongestants or caffeine that could increase your heart rate or blood pressure. Ask your pharmacist about the safe use of these products.

Certain medicines may decrease absorption of this drug into your bloodstream. Therefore, take levothyroxine 4 hours apart from:

  • calcium supplements
  • iron supplements
  • antacids
  • simethicone
  • orlistat
  • cholestyramine
  • colesevelam
  • colestipol
  • sucralfate
  • sodium polystyrene sulfonate


Certain foods may decrease absorption of this medication when taken at the same time. Take levothyroxine separately from:

  • soybean flour (soybean infant formula)
  • walnuts
  • dietary fiber


This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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