Tacrolimus IV
Generic Name: TACROLIMUS - INJECTION
Pronounced: (tack-row-LEE-muss)
Tacrolimus IV Interactions
Your doctor or pharmacist may already be aware of any possible
drug interactions and may be monitoring you for them. Do not start,
stop, or change the dosage of any medicine before checking with
your doctor or pharmacist first.
This drug should not be used with the following medications
because very serious interactions may occur:
If you are currently using any of these medications listed
above, tell your doctor or pharmacist before starting
tacrolimus.
Other drugs besides tacrolimus and ziprasidone that may affect
the heart rhythm (QTc prolongation in the EKG) include amiodarone,
dofetilide, pimozide, quinidine, sotalol, procainamide, and
clarithromycin, among others. QTc prolongation can infrequently
result in serious (rarely fatal) irregular heartbeat. Consult your
doctor or pharmacist for more details and for instructions on how
you may reduce the risk of this effect.
Before receiving this medication, tell your doctor or pharmacist
of all prescription and nonprescription/herbal products you may
use, especially of:
- drugs affecting liver enzymes that remove tacrolimus from
your body (such as cimetidine, danazol, bromocriptine,
nefazodone, ethinyl estradiol, methylprednisolone, caspofungin,
St. John's wort, azole antifungals including itraconazole,
calcium channel blockers including nifedipine, macrolide
antibiotics including erythromycin, proton pump inhibitors
including omeprazole/lansoprazole, protease inhibitors including
nelfinavir/ritonavir, rifamycins including rifampin/rifabutin,
certain anti-seizure medicines including
carbamazepine/phenytoin/phenobarbital)
- drugs that increase your potassium levels (e.g.,
potassium-sparing diuretics such as spironolactone, potassium
supplements, ACE inhibitors such as lisinopril)
- drugs that may harm the kidneys (e.g., amphotericin B,
cisplatin, ganciclovir, aminoglycosides such as gentamicin)
- sirolimus
- temsirolimus
This document does not contain all possible interactions.
Therefore, before using this product, tell your doctor or
pharmacist of all the products you use. Keep a list of all your
medications with you, and share the list with your doctor and
pharmacist.
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