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Zonalon Top

Generic Name: DOXEPIN CREAM - TOPICAL
Pronounced: (dox-EH-pin)

Zonalon Top Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

This drug should not be used with the following medications because very serious, possibly fatal interactions may occur:

  • arbutamine
  • cisapride
  • disopyramide
  • halofantrine
  • sibutramine


Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) within 2 weeks before, during, and after treatment with this medication. In some cases a serious, possibly fatal drug interaction may occur.

If you have been taking fluoxetine, wait at least 5 weeks after your last dose before starting this medication.

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting doxepin.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

  • anticholinergics (e.g., atropine, belladonna alkaloids, scopolamine, drugs for Parkinson's disease such as benztropine)
  • inhaled bronchodilators (e.g., albuterol, salmeterol)
  • certain drugs for high blood pressure (e.g., clonidine, guanadrel, guanethidine, reserpine)
  • digoxin
  • nasal decongestants (e.g., epinephrine, phenylephrine)
  • levodopa
  • lithium
  • stimulants (e.g., amphetamine, epinephrine, methylphenidate)
  • sulfonylurea anti-diabetic medication (e.g., chlorpropamide, tolazamide)
  • thyroid medication
  • valproic acid
  • drugs affecting liver enzymes that remove doxepin from your body (e.g., alcohol, barbiturates such as phenobarbital, cimetidine, haloperidol, phenothiazines such as thioridazine, St. John's wort, terbinafine, certain drugs for heart rhythm such as flecainide/propafenone, certain HIV protease inhibitors such as amprenavir/fosamprenavir, certain anti-seizure drugs such as carbamazepine/phenytoin, antidepressants such as amitriptyline, duloxetine, fluvoxamine, paroxetine, sertraline, trazodone)
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