Clomipramine Oral

In Depth

Generic Name: CLOMIPRAMINE - ORAL
Pronounced: (klo-MIP-ruh-meen)

Clomipramine Oral Interactions

Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first. (See also the How to Use section.)

This drug should not be used with the following medications because very serious interactions may occur:

arbutamine
cisapride
sibutramine

Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) within 2 weeks before, during, and after treatment with this medication. In some cases a serious, possibly fatal drug interaction may occur.

If you are currently using any of the medications listed above, tell your doctor or pharmacist before starting clomipramine.

Many drugs besides clomipramine may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, quinidine, sotalol, pimozide, procainamide, macrolide antibiotics (such as erythromycin), among others. Therefore, before using clomipramine, report all medications you are currently using to your doctor or pharmacist.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

anticholinergics (e.g., atropine, belladonna alkaloids, scopolamine)
inhaled bronchodilators (e.g., albuterol, salmeterol)
certain drugs for high blood pressure (e.g., clonidine, guanethidine, reserpine)
digoxin
nasal decongestants (e.g., epinephrine, phenylephrine)
levodopa
lithium
stimulants (e.g., amphetamine, epinephrine, methylphenidate)
thyroid supplements
valproic acid
drugs that can cause bleeding/bruising (e.g., "blood thinners" such as warfarin/heparin, anti-platelet drugs including aspirin or NSAIDs such as ibuprofen)
drugs affecting liver enzymes that remove clomipramine from your body (e.g., alcohol, barbiturates such as phenobarbital, cimetidine, haloperidol, certain drugs for heart rhythm such as flecainide/propafenone/quinidine, certain HIV protease inhibitors such as amprenavir/fosamprenavir, phenothiazines such as thioridazine, certain anti-seizure drugs such as carbamazepine/phenytoin, antidepressants such as fluvoxamine/paroxetine, St. John's wort, terbinafine)
drugs that may increase serotonin levels/activity (e.g., alprazolam, bromocriptine, buspirone, dextromethorphan, certain narcotic pain relievers such as fentanyl/meperidine/pentazocine, antidepressants such as amitriptyline/trazodone/venlafaxine, certain stimulants, S-adenosylmethionine, street drugs such as MDMA/"ecstasy," tramadol, "triptans" such as sumatriptan, tryptophan)