Rifadin IV

Rifadin IV Interactions

Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious interactions may occur:

• live bacterial vaccines (e.g., oral typhoid)
• certain non-nucleoside reverse transcriptase inhibitors (nevirapine, delavirdine, etravirine)
• voriconazole
• HIV protease inhibitors (e.g., saquinavir, ritonavir, indinavir)

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting rifampin.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.

This drug can speed up the removal of other drugs from your body by affecting certain liver enzymes. These affected drugs include:

• antiarrhythmics (e.g., disopyramide, mexiletine, quinidine)
• certain anti-cancer drugs (e.g., erlotinib, exemestane, imatinib, irinotecan)
• anticoagulants (e.g., warfarin, dicumarol)
• certain anti-infectives (e.g., chloramphenicol, clarithromycin, dapsone, doxycycline, telithromycin, zidovudine, quinolones such as ciprofloxacin)
• certain antimalarial drugs (e.g., atovaquone, quinine)
• anti-seizure drugs (e.g., phenytoin, phenobarbital, lamotrigine)
• aprepitant
• azole antifungals (e.g., itraconazole, ketoconazole)
• benzodiazepines (e.g., diazepam, midazolam)
• certain drugs to lower blood pressure (e.g., enalapril, certain beta blockers such as metoprolol and carvedilol, calcium channel blockers such as verapamil)
• caspofungin
• corticosteroids (e.g., prednisone)
• certain oral drugs for diabetes (e.g., tolbutamide, chlorpropamide, repaglinide)
• digitoxin
• certain hormone replacement drugs (e.g., estrogens such as conjugated estrogen, progestins such as medroxyprogesterone)
• certain drugs to suppress the immune system (e.g., cyclosporine, tacrolimus)
• certain drugs for mental/mood disorders (e.g., clozapine, haloperidol, tricyclic antidepressants such as amitriptyline)
• narcotic pain relievers (e.g., morphine, methadone)
• certain drugs for sleep (e.g., ramelteon, eszopiclone, zopiclone)
• certain statin drugs to lower cholesterol (e.g., atorvastatin, simvastatin)
• sulfasalazine
• theophylline
• thyroid medications (e.g., levothyroxine)

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Precautions and Side Effects