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Pyridium Plus Oral

Generic Name: PHENAZOPYRIDINE/HYOSCYAMINE/BUTABARBITAL - ORAL
Pronounced: (feh-naze-oh-PEER-ih-deen/hye-oh-SYE-uh-meen/,byoo-tuh-BARB-ih-tall)

Pyridium Plus Oral Interactions

Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious interactions may occur:

  • pramlintide
  • sodium oxybate


If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting this drug.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially:

  • antidepressants (tricyclics such as amitriptyline, MAO inhibitors such as phenelzine)
  • certain antibiotics (doxycycline, metronidazole)
  • beta blockers (e.g., metoprolol, propranolol)
  • "blood thinners" (e.g., warfarin)
  • corticosteroids (e.g., prednisone)
  • cyclosporine
  • estrogens
  • felodipine
  • potassium supplements
  • quinidine
  • theophyllines
  • valproic acid


Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicines for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone, trazodone).

Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products.

This medication may decrease the effectiveness of combination-type birth control pills. This can result in pregnancy. You may need to use an additional form of reliable birth control while using this medication. Consult your doctor or pharmacist for details.

This product can interfere with certain laboratory tests (including urine tests for kidney function, bilirubin, and sugar levels), possibly causing false test results. Home urine tests (including diabetic tests) may be affected. Make sure laboratory personnel and all your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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