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Fioricet W/Codeine Oral

Generic Name: CODEINE/BUTALBITAL/ACETAMINOPHEN/CAFFEINE - ORAL
Pronounced: (KO-deen/uh-seet-uh-MEE-no-fen/KAF-een/byou-TAL-bih-tall)

Fioricet W/Codeine Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious interactions may occur:

  • naltrexone
  • sodium oxybate


If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting this medication.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

  • adenosine
  • anticholinergic medications (e.g., scopolamine)
  • anti-seizure drugs (e.g., carbamazepine, phenytoin)
  • beta agonists (e.g., albuterol)
  • drugs affecting liver enzymes that remove this medication from your body (such as macrolide antibiotics including erythromycin, cimetidine, disulfiram, valproic acid, fluvoxamine)
  • drugs that lower blood pressure (e.g., "water pills"/diuretics such as hydrochlorothiazide, furosemide)
  • isoniazid
  • lithium
  • MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine)
  • methoxyflurane
  • other medications for pain (e.g., pentazocine, nalbuphine, morphine)
  • phenothiazines (e.g., chlorpromazine)


This drug can speed up the removal of other drugs from your body by affecting certain liver enzymes. These affected drugs include "blood thinners" (e.g., warfarin), cyclosporine, corticosteroids such as prednisone, estrogen, felodipine, metronidazole, quinidine, certain beta-blockers such as metoprolol, theophylline, doxycycline.

Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, psychiatric medicines (e.g., risperidone, amitriptyline, trazodone).

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