Etrafon 2-10 Oral

In Depth

Generic Name: PERPHENAZINE/AMITRIPTYLINE - ORAL
Pronounced: (am-eh-TRIP-teh-leen/per-FEN-uh-zeen)

Etrafon 2-10 Oral Interactions

See also Precautions section.

The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.

To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.

Some products that may interact with this drug include:

anticholinergic/antispasmodic medications (such as belladonna alkaloids, dicyclomine, scopolamine)
certain antihypertensive medications (such as clonidine, guanabenz, methyldopa)
other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen, "blood thinners" such as warfarin)
bronchodilators/decongestants/stimulants (such as albuterol, phenylephrine, amphetamines, methylphenidate)
disulfiram
thyroid supplements
MAO inhibitors (furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine)

Avoid taking MAO inhibitors within 2 weeks before, during, and after treatment with this medication. In some cases a serious (possibly fatal) drug interaction may occur.

Other medications can affect the removal of perphenazine/amitriptyline from your body, which may affect how this medication works. Examples include cimetidine, azole antifungals (such as fluconazole, ketoconazole, itraconazole), drugs to treat irregular heartbeat (such as amiodarone, flecainide, propafenone, quinidine), macrolide antibiotics (such as erythromycin), rifamycins (such as rifabutin), anti-HIV drugs (such as amprenavir, fosamprenavir, ritonavir), SSRI antidepressants (such as fluoxetine, paroxetine), St. John's wort, among others.

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