Duo-Vil 2-10 Oral

Duo-Vil 2-10 Oral Interactions

See also How to Use section.

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

This drug should not be used with the following medications because very serious interactions may occur:

• drugs with effects on dopamine (e.g., cabergoline, pergolide)
• lumefantrine
• sibutramine
• iomeprol
• metrizamide

Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine) within 2 weeks before, during, and after treatment with this medication. In some cases a serious (possibly fatal) drug interaction may occur.

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting amitriptyline.

Other drugs besides amitriptyline that may affect the heart rhythm (QT prolongation in the EKG) include pimozide, cisapride, halofantrine, disopyramide, grepafloxacin and sparfloxacin, among others. Before using this drug, report all medications you are currently using to your doctor or pharmacist. QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (e.g., severe dizziness, fainting) that require immediate medical attention. Ask your doctor or pharmacist for more details and for instructions on how you may reduce the risk of this effect.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

• anticholinergic medications (e.g., dicyclomine, scopolamine)
• certain antihypertensive medications (clonidine, guanadrel, guanethidine)
• "blood thinners" (e.g., warfarin)
• certain anti-HIV drugs (amprenavir, fosamprenavir, ritonavir)
• barbiturates (e.g., phenobarbital)
• disulfiram
• drugs affecting liver enzymes that remove amitriptyline or perphenazine from your body (e.g., amiodarone, cimetidine, fluconazole, SSRI antidepressants including fluoxetine/paroxetine)
• drugs for heart rhythm (e.g., flecainide, propafenone, quinidine)
• drugs that increase the risk for seizures (e.g., alcohol, bupropion, isoniazid, tramadol, other antipsychotic medications such as haloperidol/quetiapine)
• drugs for Parkinson's disease (e.g., bromocriptine, levodopa)
• ethchlorvynol
• lithium
• St John's wort
• stimulants (e.g., amphetamines, methylphenidate)
• certain sympathomimetics (e.g., albuterol, epinephrine, phenylephrine)
• terbinafine
• thyroid supplements
• other tricyclic antidepressants (e.g., nortriptyline)

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