Rifamate Oral

In Depth

Generic Name: RIFAMPIN/ISONIAZID - ORAL
Pronounced: (riff-AM-pin/eye-so-NYE-uh-zid)

Rifamate Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

This drug should not be used with the following medications because very serious interactions may occur:

ketoconazole
itraconazole
voriconazole
HIV protease inhibitors (e.g., indinavir, ritonavir)
delavirdine
nevirapine
etravirine

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting rifampin/isoniazid.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

acetaminophen
probenecid

This drug can speed up the removal of other drugs from your body by affecting certain liver enzymes. These affected drugs include:

antiarrhythmics (e.g., mexiletine, disopyramide, propafenone)
certain antibiotics (e.g., fluoroquinolones such as ciprofloxacin, clarithromycin, erythromycin, doxycycline, chloramphenicol, cotrimoxazole, telithromycin)
antidiabetics (e.g., glyburide, glimepiride, repaglinide)
certain antimalarial drugs (e.g., mefloquine, atovaquone)
anti-seizure medications (e.g., phenytoin, lamotrigine, valproic acid, carbamazepine)
aprepitant
barbiturates (e.g., phenobarbital)
benzodiazepines (e.g., diazepam, triazolam)
digoxin
estrogens
certain cancer drugs (e.g., exemestane, sunitinib, gefitinib, erlotinib, imatinib, irinotecan, tamoxifen)
certain drugs that suppress the immune system (e.g., cyclosporine, tacrolimus)
corticosteroids (e.g., prednisone, dexamethasone)
certain drugs to treat high blood pressure (e.g., beta blockers such as propranolol/metoprolol, calcium channel blockers such as verapamil/nifedipine, enalapril, losartan)
certain other HIV-medications (e.g., efavirenz)
methadone
nortriptyline
certain psychiatric medications (e.g., haloperidol, quetiapine, buspirone)
certain "statin" cholesterol medications (e.g., simvastatin, fluvastatin)
sulfasalazine
theophylline
thyroid medications (e.g., levothyroxine)
warfarin
zolpidem