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Bactrim DS Oral

Generic Name: SULFAMETHOXAZOLE/TRIMETHOPRIM- ORAL
Pronounced: (sull-fuh-meth-OX-uh-zole/try-METH-oh-prim)

Bactrim DS Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious interactions may occur:

  • dofetilide
  • methenamine


If you are currently using any of these medications tell your doctor or pharmacist before starting sulfamethoxazole with trimethoprim.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

  • certain anti-diabetic medications (e.g., glipizide, glyburide, tolbutamide)
  • "blood thinners" (e.g., warfarin)
  • cyclosporine
  • digoxin
  • drugs which can increase potassium levels (e.g., ACE inhibitors such as captopril, lisinopril)
  • hydantoins (e.g., phenytoin)
  • live vaccines
  • methotrexate
  • oral PABA
  • procainamide
  • pyrimethamine
  • tricyclic antidepressants (e.g., amitriptyline)
  • certain "water pills" (thiazide diuretics such as hydrochlorothiazide)


This medication may decrease the effectiveness of combination-type birth control pills. This can result in pregnancy. You may need to use an additional form of reliable birth control while using this medication. Consult your doctor or pharmacist for details.

This product can affect the results of certain lab tests. Make sure laboratory personnel and your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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