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Darvon Compound-65 Oral

  • certain antihistamines (e.g., diphenhydramine)
  • medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem)
  • muscle relaxants
  • psychiatric medicines (e.g., chlorpromazine, risperidone, amitriptyline, trazodone)


Check the labels on all your medicines (e.g., cough-and-cold products, other headache medications) because they may contain aspirin, caffeine, or ingredients that cause drowsiness. Also keep in mind that certain beverages (e.g., coffee, colas, tea) contain caffeine. Avoid drinking large amounts of caffeinated beverages while taking this medication because severe nervousness and irritability can occur. Ask your pharmacist about using those products safely.

Also check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (NSAIDs such as ibuprofen/naproxen) that are similar to this drug and may increase your risk for side effects if taken together with this medication.

This medication may interfere with certain medical/laboratory tests (including fasting blood glucose, cholesterol levels, prothrombin time, urine 5-HIAA levels, amylase and lipase levels, certain urine glucose tests, dipyridamole-thallium imaging tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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